//     NOELIA JACOBO PIQUERAS

Tuluc Research Group
Institute of Pharmacy, Dept. of Pharmacology and Toxicology
University of Innsbruck

//     INFORMATION

Nationality: Spanish
Education: MSc in Biomedicine (Alicante, Spain)
E-Mail: noelia.jacobo-piqueras@uibk.ac.at
ORCID
Supervisor: Assoc.-Prof. Dr. Petronel Tuluc

//     PROJECT

Sex difference in diabetes

In humans, the incidence of Type 2 Diabetes Mellitus (T2DM) has a clear sexual dimorphism, a phenotype recapitulated by many rodent T2DM models. Nevertheless, the main reason has been proposed to be the sex difference in insulin sensitivity. Previously we demonstrated that deletion of α2δ-1, an auxiliary subunit of the high voltage gated calcium channel (HVCC), leads to diabetes in mice in a sex-specific manner despite a similar insulin sensitivity. In my project, we aim to investigate the molecular mechanisms that lead to a higher insulin release in females compared to males.

Methods Primary pancreatic β-cell culture, Electrophysiology (current and voltage clamp), Capacitance measurements, Calcium imaging, Mouse handling and breeding, Dynamic hormone release, MEA.

//     INTERNAL COLLABORATIONS

Flucher Group
Campiglio Group
Koschak Group

//    EXTERNAL COLLABORATIONS

Prof. Emilio Carbone, Dipartimento di Scienza e Tecnologia del Farmaco (Torino, IT)