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// PUBLICATIONS

of the CavX consortium in the last years (2018-2024) – PubMed search

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2018

2024

Inactivation induced by pathogenic Ca_v1.3 L-type Ca²⁺-channel variants enhances sensitivity for dihydropyridine Ca²⁺ channel blockers.
Török F, Salamon S, Ortner NJ, Fernández-Quintero ML, Matthes J, Striessnig J. Br J Pharmacol. 2024 Oct 7. doi: 10.1111/bph.17357. Online ahead of print. PMID: 39370994

Assessing AF2’s ability to predict structural ensembles of proteins
Riccabona JR, Spoendlin FC, Fischer AM, Loeffler JR, Quoika PK, Jenkins TP, Ferguson JA, Smorodina E, Laustsen AH, Greiff V, Forli S, Ward AB, Deane CM, Fernández-Quintero ML. Structure. 2024 Sep 20:S0969-2126(24)00370-8. doi: 10.1016/j.str.2024.09.001. Online ahead of print. PMID: 39332396

First report of a bla_NDM-producing extensively drug resistant Klebsiella pneumoniae ST437 in Italy
Ranieri SC, Fabbrizi V, D’ Amario AM, Frascella MG, Di Biase V, Di Francesco C, Di Sante S, De Berardis L, De Martinis M, Partenza M, Chiaverini A, Centorotola G, Cammà C, Pomilio F, Cornacchia A. Front Cell Infect Microbiol. 2024 Sep 11;14:1426817. doi: 10.3389/fcimb.2024.1426817. eCollection 2024. PMID: 39324055 Free PMC article.

A Novel De Novo Gain-of-Function CACNA1D Variant in Neurodevelopmental Disease With Congenital Tremor, Seizures, and Hypotonia
Dannenberg F, Von Moers A, Bittigau P, Lange J, Wiegand S, Török F, Stölting G, Striessnig J, Motazacker MM, Broekema MF, Schuelke M, Kaindl AM, Scholl UI, Ortner NJ. Neurol Genet. 2024 Sep 6;10(5):e200186. doi: 10.1212/NXG.0000000000200186. eCollection 2024 Oct. PMID: 39246741 Free PMC article.

Ca_V1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling
Pelizzari S, Heiss MC, Fernández-Quintero ML, El Ghaleb Y, Liedl KR, Tuluc P, Campiglio M, Flucher BE. Nat Commun. 2024 Aug 28;15(1):7440. doi: 10.1038/s41467-024-51809-5. PMID: 39198449 Free PMC article.

A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α₂δ-2
Haddad S, Ablinger C, Stanika R, Hessenberger M, Campiglio M, Ortner NJ, Tuluc P, Obermair GJ. J Neurochem. 2024 Aug 19. doi: 10.1111/jnc.16197. Online ahead of print. PMID: 39161180

Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Tulika T, Ruso-Julve F, Ahmadi S, Ljungars A, Rivera-de-Torre E, Wade J, Fernández-Quintero ML, Jenkins TP, Belfakir SB, Ross GMS, Boyens-Thiele L, Buell AK, Sakya SA, Sørensen CV, Bohn MF, Ledsgaard L, Voldborg BG, Francavilla C, Schlothauer T, Lomonte B, Andersen JT, Laustsen AH. Structure. 2024 Sep 5;32(9):1404-1418.e7. doi: 10.1016/j.str.2024.07.014. Epub 2024 Aug 14. PMID: 39146931 Free PMC article.

STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance
Witalisz-Siepracka A, Denk CM, Zdársky B, Hofmann L, Edtmayer S, Harm T, Weiss S, Heindl K, Hessenberger M, Summer S, Dutta S, Casanova E, Obermair GJ, Győrffy B, Putz EM, Sill H, Stoiber D. Front Immunol. 2024 Jul 5;15:1374068. doi: 10.3389/fimmu.2024.1374068. eCollection 2024. PMID: 39034990 Free PMC article.

Deletion of the α₂δ-1 calcium channel subunit increases excitability of mouse chromaffin cells
Geisler SM, Ottaviani MM, Jacobo-Piqueras N, Theiner T, Mastrolia V, Guarina L, Ebner K, Obermair GJ, Carbone E, Tuluc P. J Physiol. 2024 Aug;602(15):3793-3814. doi: 10.1113/JP285681. Epub 2024 Jul 14. PMID: 39004870

Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile
Rodriguez Rodriguez ER, Nordvang RT, Petersson M, Rendsvig JKH, Arendrup EW, Fernández Quintero ML, Jenkins TP, Laustsen AH, Thrane SW. Protein Sci. 2024 Jul;33(7):e5035. doi: 10.1002/pro.5035. PMID: 38923049

Spatial transcriptomics in embryonic mouse diaphragm muscle reveals regional gradients and subdomains of developmental gene expression
Kaplan MM, Zeidler M, Knapp A, Hölzl M, Kress M, Fritsch H, Krogsdam A, Flucher BE. iScience. 2024 May 17;27(6):110018. doi: 10.1016/j.isci.2024.110018. eCollection 2024 Jun 21. PMID: 38883818

Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells
Voorn RA, Sternbach M, Jarysta A, Rankovic V, Tarchini B, Wolf F, Vogl C. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589153. doi: 10.1101/2024.04.12.589153. PMID: 38659872

Novel protocol for multiple-dose oral administration of the L-type Ca²⁺ channel blocker isradipine in mice: A dose-finding pharmacokinetic study
Theiner T, Ortner NJ, Oberacher H, Stojanovic G, Tuluc P, Striessnig J. Channels (Austin). 2024 Dec;18(1):2335469. doi: 10.1080/19336950.2024.2335469. Epub 2024 Apr 2. PMID: 38564754

Pathogenicity of de novo CACNA1D Ca²⁺ channel variants predicted from sequence co-variation
Tang X, Ortner NJ, Nikonishyna YV, Fernández-Quintero ML, Kokot J, Striessnig J, Liedl KR. Eur J Hum Genet. 2024 Mar 29. doi: 10.1038/s41431-024-01594-y. Online ahead of print. PMID: 38553610

Ferroelectric Phase Transition in Barium Titanate Revisited with Ab Initio Molecular Dynamics
Ludt C, Meyer DC, Zschornak M. Materials (Basel). 2024 Feb 23;17(5):1023. doi: 10.3390/ma17051023. PMID: 38473495

The Role of Force Fields and Water Models in Protein Folding and Unfolding Dynamics
Fischer AM, Tichy A, Kokot J, Hoerschinger VJ, Wild RF, Riccabona JR, Loeffler JR, Waibl F, Quoika PK, Gschwandtner P, Forli S, Ward AB, Liedl KR, Zacharias M, Fernández-Quintero ML. J Chem Theory Comput. 2024 Mar 12;20(5):2321-2333. doi: 10.1021/acs.jctc.3c01106. Epub 2024 Feb 19. PMID: 38373307

Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β cells
Jacobo-Piqueras N, Theiner T, Geisler SM, Tuluc P. JCI Insight. 2024 Feb 15;9(6):e171609. doi: 10.1172/jci.insight.171609. PMID: 38358819 Free PMC article.

Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies
Marini-Rapoport O, Fernández-Quintero ML, Keswani T, Zong G, Shim J, Pedersen LC, Mueller GA, Patil SU. Clin Exp Immunol. 2024 Mar 12;216(1):25-35. doi: 10.1093/cei/uxae005. PMID: 38346116

Broadly inhibitory antibodies against severe malaria virulence proteins
Reyes RA, Raghavan SSR, Hurlburt NK, Introini V, Kana IH, Jensen RW, Martinez-Scholze E, Gestal-Mato M, Bau CB, Fernández-Quintero ML, Loeffler JR, Ferguson JA, Lee WH, Martin GM, Theander TG, Ssewanyana I, Feeney ME, Greenhouse B, Bol S, Ward AB, Bernabeu M, Pancera M, Turner L, Bunnik EM, Lavstsen T. bioRxiv [Preprint]. 2024 Jan 25:2024.01.25.577124. doi: 10.1101/2024.01.25.577124. PMID: 38328068 Free PMC article. Preprint.

Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels
Del Rivero Morfin PJ, Kochiss AL, Liedl KR, Flucher BE, Fernández-Quintero MLI, Ben-Johny M. J Gen Physiol. 2024 Feb 5;156(2):e202313365. doi: 10.1085/jgp.202313365. Epub 2024 Jan 4. PMID: 38175169

Treatment of multiple-beam X-ray diffraction in energy-dependent measurements
Nentwich M, Zschornak M, Weigel T, Köhler T, Novikov D, Meyer DC, Richter C. J Synchrotron Radiat. 2024 Jan 1;31(Pt 1):28-34. doi: 10.1107/S1600577523009670. Epub 2024 Jan 1. PMID: 38095667 Free PMC article.

Excitation-secretion coupling in chromaffin cells of the adrenal gland: Where does calcium come from?
Tuluc P, Carbone E. Pflugers Arch. 2024 Jan;476(1):3-4. doi: 10.1007/s00424-023-02867-z. Epub 2023 Oct 16. PMID: 37843577 Free PMC article. No abstract available.

2023

The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA, Ahlers-Dannen KE, Alqinyah M, Arumugam TV, Bodle C, Dagner JB, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Layeghi-Ghalehsoukhteh S, Lee JK, Luo Z, Martemyanov K, Mascarenhas LD, McNabb H, Montañez-Miranda C, Ogujiofor O, Phan H, Roman DL, Shaw V, Sjogren B, Sobey C, Spicer MM, Squires KE, Sutton L, Wendimu M, Wilkie T, Xie K, Zhang Q, Zolghadri Y. Br J Pharmacol. 2023 Oct;180 Suppl 2:S1-S22. doi: 10.1111/bph.16176. PMID: 38123153 Review.

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. Br J Pharmacol. 2023 Oct;180 Suppl 2:S145-S222. doi: 10.1111/bph.16178. PMID: 38123150

Structural Basis of the Immunological Cross-Reactivity between Kiwi and Birch Pollen
Zeindl R, Franzmann AL, Fernández-Quintero ML, Seidler CA, Hoerschinger VJ, Liedl KR, Tollinger M. Foods. 2023 Oct 27;12(21):3939. doi: 10.3390/foods12213939. PMID: 37959058 Free PMC article.

Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity
Tang X, Kokot J, Waibl F, Fernández-Quintero ML, Kamenik AS, Liedl KR. J Chem Inf Model. 2023 Nov 27;63(22):7107-7123. doi: 10.1021/acs.jcim.3c01123. Epub 2023 Nov 9. PMID: 37943023 Free PMC article.

PEP-Patch: Electrostatics in Protein-Protein Recognition, Specificity, and Antibody Developability
Hoerschinger VJ, Waibl F, Pomarici ND, Loeffler JR, Deane CM, Georges G, Kettenberger H, Fernández-Quintero ML, Liedl KR. J Chem Inf Model. 2023 Nov 27;63(22):6964-6971. doi: 10.1021/acs.jcim.3c01490. Epub 2023 Nov 7. PMID: 37934909 Free PMC article.

Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library
Tulika T, Pedersen RW, Rimbault C, Ahmadi S, Rivera-de-Torre E, Fernández-Quintero ML, Loeffler JR, Bohn MF, Ljungars A, Ledsgaard L, Voldborg BG, Ruso-Julve F, Andersen JT, Laustsen AH. Protein Sci. 2023 Dec;32(12):e4821. doi: 10.1002/pro.4821. PMID: 37897425 Free PMC article.

Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines
Fernández-Quintero ML, Pomarici ND, Fischer AM, Hoerschinger VJ, Kroell KB, Riccabona JR, Kamenik AS, Loeffler JR, Ferguson JA, Perrett HR, Liedl KR, Han J, Ward AB. Antibodies (Basel). 2023 Oct 18;12(4):67. doi: 10.3390/antib12040067. PMID: 37873864 Free PMC article. Review.

Excitation-secretion coupling in chromaffin cells of the adrenal gland: Where does calcium come from?
Tuluc P, Carbone E. Pflugers Arch. 2024 Jan;476(1):3-4. doi: 10.1007/s00424-023-02867-z. Epub 2023 Oct 16. PMID: 37843577 Free PMC article. No abstract available.

Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of Ca _V 1.3 Channels
Del Rivero Morfin PJ, Kochiss AL, Liedl KR, Flucher BE, Fernández-Quintero MLI, Ben-Johny M. bioRxiv. 2023 Sep 23:2023.09.21.558864. doi: 10.1101/2023.09.21.558864. Preprint. PMID: 37790368 Free PMC article.

The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice
Ortner NJ, Sah A, Paradiso E, Shin J, Stojanovic S, Hammer N, Haritonova M, Hofer NT, Marcantoni A, Guarina L, Tuluc P, Theiner T, Pitterl F, Ebner K, Oberacher H, Carbone E, Stefanova N, Ferraguti F, Singewald N, Roeper J, Striessnig J. JCI Insight. 2023 Sep 12:e162100. doi: 10.1172/jci.insight.162100. Online ahead of print. PMID: 37698939 Free article.

Age-dependent structural reorganization of utricular ribbon synapses
Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Gonzalez PA, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO, Wichmann C. Front Cell Dev Biol. 2023 Aug 10;11:1178992. doi: 10.3389/fcell.2023.1178992. eCollection 2023. PMID: 37635868 Free PMC article.

An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity
Stanika R, Obermair GJ. Bio Protoc. 2023 Jul 20;13(14):e4761. doi: 10.21769/BioProtoc.4761. eCollection 2023 Jul 20. PMID: 37497454 Free PMC article.

Defining and Studying B Cell Receptor and TCR Interactions
Rappazzo CG, Fernández-Quintero ML, Mayer A, Wu NC, Greiff V, Guthmiller JJ. J Immunol. 2023 Aug 1;211(3):311-322. doi: 10.4049/jimmunol.2300136. PMID: 37459189

Establishing a cell-based screening workflow for determining the efficiency of CYP2C9 metabolism: moving towards the use of breath volatiles in personalised medicine
Lochmann F, Nikolajevic A, Stock V, Kammerer S, Fernández-Quintero ML, Loeffler JR, Liedl KR, Troppmair J, Mayhew CA, Ruzsanyi V. J Breath Res. 2023 Jul 19;17(4). doi: 10.1088/1752-7163/ace46f. PMID: 37406623

Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node
Shrestha N, Zorn-Pauly K, Mesirca P, Koyani CN, Wölkart G, Di Biase V, Torre E, Lang P, Gorischek A, Schreibmayer W, Arnold R, Maechler H, Mayer B, von Lewinski D, Torrente AG, Mangoni ME, Pelzmann B, Scheruebel S. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2210152120. doi: 10.1073/pnas.2210152120. Epub 2023 Jul 5. PMID: 37406102

Cross-linking disulfide bonds govern solution structures of diabodies
Math BA, Waibl F, Lamp LM, Fernández-Quintero ML, Liedl KR. Proteins. 2023 Sep;91(9):1316-1328. doi: 10.1002/prot.26509. Epub 2023 Jun 28. PMID: 37376973

Evolution of the Immunoglobulin Isotypes-Variations of Biophysical Properties among Animal Classes
Pomarici ND, Cacciato R, Kokot J, Fernández-Quintero ML, Liedl KR. Biomolecules. 2023 May 8;13(5):801. doi: 10.3390/biom13050801. PMID: 37238671 Free PMC article.

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9
Martin GM, Fernández-Quintero ML, Lee WH, Pholcharee T, Eshun-Wilson L, Liedl KR, Pancera M, Seder RA, Wilson IA, Ward AB. Nat Commun. 2023 May 17;14(1):2815. doi: 10.1038/s41467-023-38509-2. PMID: 37198165 Free PMC article.

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein
Lechable M, Tang X, Siebert S, Feldbacher A, Fernández-Quintero ML, Breuker K, Juliano CE, Liedl KR, Hobmayer B, Hartl M. Cells. 2023 Apr 26;12(9):1265. doi: 10.3390/cells12091265. PMID: 37174665 Free PMC article.

Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification
Gollmann-Tepeköylü C, Graber M, Hirsch J, Mair S, Naschberger A, Pölzl L, Nägele F, Kirchmair E, Degenhart G, Demetz E, Hilbe R, Chen HY, Engert JC, Böhm A, Franz N, Lobenwein D, Lener D, Fuchs C, Weihs A, Töchterle S, Vogel GF, Schweiger V, Eder J, Pietschmann P, Seifert M, Kronenberg F, Coassin S, Blumer M, Hackl H, Meyer D, Feuchtner G, Kirchmair R, Troppmair J, Krane M, Weiss G, Tsimikas S, Thanassoulis G, Grimm M, Rupp B, Huber LA, Zhang SY, Casanova JL, Tancevski I, Holfeld J. Circulation. 2023 May 16;147(20):1518-1533. doi: 10.1161/CIRCULATIONAHA.122.063481. Epub 2023 Apr 4. PMID: 37013819

Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels
Heigl T, Netzer MA, Zanetti L, Ganglberger M, Fernández-Quintero ML, Koschak A. Channels (Austin). 2023 Dec;17(1):2192360. doi: 10.1080/19336950.2023.2192360. PMID: 36943941 Free PMC article.

Structural mechanism of Fab domain dissociation as a measure of interface stability
Pomarici ND, Waibl F, Quoika PK, Bujotzek A, Georges G, Fernández-Quintero ML, Liedl KR. J Comput Aided Mol Des. 2023 Apr;37(4):201-215. doi: 10.1007/s10822-023-00501-9. Epub 2023 Mar 15. PMID: 36918473 Free PMC article.

Structural Characterization of Nanobodies during Germline Maturation
Seidler CA, Kokot J, Fernández-Quintero ML, Liedl KR. Biomolecules. 2023 Feb 17;13(2):380. doi: 10.3390/biom13020380. PMID: 36830754 Free PMC article.

Assessing developability early in the discovery process for novel biologics
Fernández-Quintero ML, Ljungars A, Waibl F, Greiff V, Andersen JT, Gjølberg TT, Jenkins TP, Voldborg BG, Grav LM, Kumar S, Georges G, Kettenberger H, Liedl KR, Tessier PM, McCafferty J, Laustsen AH. MAbs. 2023 Jan-Dec;15(1):2171248. doi: 10.1080/19420862.2023.2171248. PMID: 36823021 Free PMC article. Review.

Ca_v 1.3-selective inhibitors of voltage-gated L-type Ca²⁺ channels: Fact or (still) fiction?
Filippini L, Ortner NJ, Kaserer T, Striessnig J. Br J Pharmacol. 2023 May;180(10):1289-1303. doi: 10.1111/bph.16060. Epub 2023 Mar 14. PMID: 36788128 Review.

Challenges in antibody structure prediction
Fernández-Quintero ML, Kokot J, Waibl F, Fischer AM, Quoika PK, Deane CM, Liedl KR. MAbs. 2023 Jan-Dec;15(1):2175319. doi: 10.1080/19420862.2023.2175319. PMID: 36775843 Free PMC article.

A novel calcium channel Cavβ₂ splice variant with unique properties predominates in the retina
Seitter H, Obkircher J, Grabher P, Hartl J, Zanetti L, Lux UT, Fotakis G, Fernández-Quintero ML, Kaserer T, Koschak A. J Biol Chem. 2023 Apr;299(4):102972. doi: 10.1016/j.jbc.2023.102972. Epub 2023 Feb 2. PMID: 36738788 Free PMC article.

Pathophysiological Roles of Auxiliary Calcium Channel α₂δ Subunits
Hessenberger M, Haddad S, Obermair GJ. Handb Exp Pharmacol. 2023;279:289-316. doi: 10.1007/164_2022_630. PMID: 36598609

Ca_V3.3 Channelopathies
El Ghaleb Y, Flucher BE. Handb Exp Pharmacol. 2023;279:263-288. doi: 10.1007/164_2022_631. PMID: 36592228

Ca_V1.1 Calcium Channel Signaling Complexes in Excitation-Contraction Coupling: Insights from Channelopathies
Campiglio M, Dyrda A, Tuinte WE, Török E. Handb Exp Pharmacol. 2023;279:3-39. doi: 10.1007/164_2022_627. PMID: 36592225

CACNA1D-Related Channelopathies: From Hypertension to Autism
Ortner NJ. Handb Exp Pharmacol. 2023;279:183-225. doi: 10.1007/164_2022_626. PMID: 36592224 Review.

Mitochondrial network expansion and dynamic redistribution during islet morphogenesis in zebrafish larvae
Freudenblum J, Meyer D, Kimmel RA. FEBS Lett. 2023 Jan;597(2):262-275. doi: 10.1002/1873-3468.14508. Epub 2022 Oct 19. PMID: 36217213 Free PMC article.

Germline de novo variant F747S extends the phenotypic spectrum of CACNA1D Ca2+ channelopathies
Török F, Tezcan K, Filippini L, Fernández-Quintero ML, Zanetti L, Liedl KR, Drexel RS, Striessnig J, Ortner NJ. Hum Mol Genet. 2023 Feb 19;32(5):847-859. doi: 10.1093/hmg/ddac248. PMID: 36208199 Free PMC article.

Thermostabilizing mechanisms of canonical single amino acid substitutions at a GH1 β-glucosidase probed by multiple MD and computational approaches
Rocha REO, Mariano DCB, Almeida TS, CorrêaCosta LS, Fischer PHC, Santos LH, Caffarena ER, da Silveira CH, Lamp LM, Fernandez-Quintero ML, Liedl KR, de Melo-Minardi RC, de Lima LHF. Proteins. 2023 Feb;91(2):218-236. doi: 10.1002/prot.26424. Epub 2022 Oct 10. PMID: 36114781

2022

Monoallelic loss of the F-actin-binding protein radixin facilitates startle reactivity and pre-pulse inhibition in mice

Hausrat TJ, Vogl C, Neef J, Schweizer M, Yee BK, Strenzke N, Kneussel M. Front Cell Dev Biol. 2022 Nov 28;10:987691. doi: 10.3389/fcell.2022.987691. eCollection 2022. PMID: 36518539 Free PMC article.

Bispecific antibodies-effects of point mutations on CH3-CH3 interface stability

Pomarici ND, Fernández-Quintero ML, Quoika PK, Waibl F, Bujotzek A, Georges G, Liedl KR. Protein Eng Des Sel. 2022 Feb 17;35:gzac012. doi: 10.1093/protein/gzac012. PMID: 36468666 Free PMC article.

Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 Gene CACNA1D Associated with Familial Sinus Node Dysfunction and Focal Idiopathic Epilepsy

Rinné S, Stallmeyer B, Pinggera A, Netter MF, Matschke LA, Dittmann S, Kirchhefer U, Neudorf U, Opp J, Striessnig J, Decher N, Schulze-Bahr E. Int J Mol Sci. 2022 Nov 17;23(22):14215. doi: 10.3390/ijms232214215. PMID: 36430690 Free PMC article.

pH-dependent structural diversity of profilin allergens determines thermal stability

Hofer F, Fischer AL, Kamenik AS, Waibl F, Fernández-Quintero ML, Liedl KR. Front Allergy. 2022 Oct 17;3:1007000. doi: 10.3389/falgy.2022.1007000. eCollection 2022. PMID: 36324331 Free PMC article.

Mitochondrial network expansion and dynamic redistribution during islet morphogenesis in zebrafish larvae

Freudenblum J, Meyer D, Kimmel RA. FEBS Lett. 2023 Jan;597(2):262-275. doi: 10.1002/1873-3468.14508. Epub 2022 Oct 19. PMID: 36217213 Free PMC article.

Prevention of Oxidative Damage in Spinal Cord Ischemia Upon Aortic Surgery: First-In-Human Results of Shock Wave Therapy Prove Safety and Feasibility

Graber M, Nägele F, Röhrs BT, Hirsch J, Pölzl L, Moriggl B, Mayr A, Troger F, Kirchmair E, Wagner JF, Nowosielski M, Mayer L, Voelkl J, Tancevski I, Meyer D, Grimm M, Knoflach M, Holfeld J, Gollmann-Tepeköylü C. J Am Heart Assoc. 2022 Oct 18;11(20):e026076. doi: 10.1161/JAHA.122.026076. Epub 2022 Oct 10. PMID: 36216458 Free PMC article.

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Fernández-Quintero ML, Fischer AM, Kokot J, Waibl F, Seidler CA, Liedl KR. Front Immunol. 2022 Sep 2;13:953917. doi: 10.3389/fimmu.2022.953917. eCollection 2022. PMID: 36177031 Free PMC article.

STAC3 determines the slow activation kinetics of Ca_V 1.1 currents and inhibits its voltage-dependent inactivation

Tuinte WE, Török E, Mahlknecht I, Tuluc P, Flucher BE, Campiglio M. J Cell Physiol. 2022 Nov;237(11):4197-4214. doi: 10.1002/jcp.30870. Epub 2022 Sep 26. PMID: 36161458

Charge-Converting Nanoemulsions as Promising Retinal Drug and Gene Delivery Systems

Nguyen Le NM, Zsák S, Le-Vinh B, Friedl JD, Kali G, Knoll P, Seitter HW, Koschak A, Bernkop-Schnürch A. ACS Appl Mater Interfaces. 2022 Oct 5;14(39):44981-44991. doi: 10.1021/acsami.2c11649. Epub 2022 Sep 20. PMID: 36125912 Free PMC article.

Comparison of hydrophobicity scales for predicting biophysical properties of antibodies

Waibl F, Fernández-Quintero ML, Wedl FS, Kettenberger H, Georges G, Liedl KR. Front Mol Biosci. 2022 Aug 31;9:960194. doi: 10.3389/fmolb.2022.960194. eCollection 2022. PMID: 36120542 Free PMC article.

Thermostabilizing mechanisms of canonical single amino acid substitutions at a GH1 β-glucosidase probed by multiple MD and computational approaches

Rocha REO, Mariano DCB, Almeida TS, CorrêaCosta LS, Fischer PHC, Santos LH, Caffarena ER, da Silveira CH, Lamp LM, Fernandez-Quintero ML, Liedl KR, de Melo-Minardi RC, de Lima LHF. Proteins. 2023 Feb;91(2):218-236. doi: 10.1002/prot.26424. Epub 2022 Oct 10. PMID: 36114781

α₂δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions

Ablinger C, Eibl C, Geisler SM, Campiglio M, Stephens GJ, Missler M, Obermair GJ. Int J Mol Sci. 2022 Aug 31;23(17):9885. doi: 10.3390/ijms23179885. PMID: 36077281 Free PMC article.

The Structural Flexibility of PR-10 Food Allergens

Führer S, Unterhauser J, Zeindl R, Eidelpes R, Fernández-Quintero ML, Liedl KR, Tollinger M. Int J Mol Sci. 2022 Jul 26;23(15):8252. doi: 10.3390/ijms23158252. PMID: 35897827 Free PMC article.

A multicenter performance evaluation of the new Elecsys Vitamin D total III assay versus reference isotope dilution liquid chromatography tandem mass spectrometry and commercially available comparators

Findeisen P, Leis M, Bendig G, Grimme J, Moser E, Vogl C, Christenson R. J Clin Lab Anal. 2022 Sep;36(9):e24610. doi: 10.1002/jcla.24610. Epub 2022 Jul 19. PMID: 35852988 Free PMC article.

β2-subunit alternative splicing stabilizes Cav2.3 Ca²⁺ channel activity during continuous midbrain dopamine neuron-like activity

Siller A, Hofer NT, Tomagra G, Burkert N, Hess S, Benkert J, Gaifullina A, Spaich D, Duda J, Poetschke C, Vilusic K, Fritz EM, Schneider T, Kloppenburg P, Liss B, Carabelli V, Carbone E, Ortner NJ, Striessnig J. Elife. 2022 Jul 6;11:e67464. doi: 10.7554/eLife.67464. PMID: 35792082 Free PMC article.

Ca_v1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons

Shin J, Kovacheva L, Thomas D, Stojanovic S, Knowlton CJ, Mankel J, Boehm J, Farassat N, Paladini C, Striessnig J, Canavier CC, Geisslinger G, Roeper J. Sci Adv. 2022 Jun 10;8(23):eabm4560. doi: 10.1126/sciadv.abm4560. Epub 2022 Jun 8. PMID: 35675413 Free PMC article.

Grid inhomogeneous solvation theory for cross-solvation in rigid solvents

Waibl F, Kraml J, Hoerschinger VJ, Hofer F, Kamenik AS, Fernández-Quintero ML, Liedl KR. J Chem Phys. 2022 May 28;156(20):204101. doi: 10.1063/5.0087549. PMID: 35649837

Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR

Fernández-Quintero ML, DeRose EF, Gabel SA, Mueller GA, Liedl KR. Int J Mol Sci. 2022 May 12;23(10):5419. doi: 10.3390/ijms23105419. PMID: 35628231 Free PMC article.

Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1

El Ghaleb Y, Ortner NJ, Posch W, Fernández-Quintero ML, Tuinte WE, Monteleone S, Draheim HJ, Liedl KR, Wilflingseder D, Striessnig J, Tuluc P, Flucher BE, Campiglio M. J Gen Physiol. 2022 Sep 5;154(9):e202113028. doi: 10.1085/jgp.202113028. Epub 2022 Mar 29. PMID: 35349630 Free PMC article.

Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase

Werner ER, Fernández-Quintero ML, Hulo N, Golderer G, Sailer S, Lackner K, Werner-Felmayer G, Liedl KR, Watschinger K. Cell Mol Life Sci. 2022 Mar 28;79(4):214. doi: 10.1007/s00018-022-04238-w. PMID: 35347434 Free PMC article.

Counteractive and cooperative actions of muscle β-catenin and Ca_V1.1 during early neuromuscular synapse formation

Kaplan MM, Flucher BE. iScience. 2022 Mar 4;25(4):104025. doi: 10.1016/j.isci.2022.104025. eCollection 2022 Apr 15. PMID: 35340430 Free PMC article.

Permanent Laser Scanner and Synthetic Aperture Radar Data: Correlation Characterisation at a Sandy Beach

Di Biase V, Kuschnerus M, Lindenbergh RC. Sensors (Basel). 2022 Mar 16;22(6):2311. doi: 10.3390/s22062311. PMID: 35336482 Free PMC article.

Methods for multiscale structural and functional analysis of the mammalian cochlea

Vogl C, Neef J, Wichmann C. Mol Cell Neurosci. 2022 May;120:103720. doi: 10.1016/j.mcn.2022.103720. Epub 2022 Mar 11. PMID: 35288271 Review.

Corrigendum: Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Fernández-Quintero ML, Quoika PK, Wedl FS, Seidler CA, Kroell KB, Loeffler JR, Pomarici ND, Hoerschinger VJ, Bujotzek A, Georges G, Kettenberger H, Liedl KR. Front Mol Biosci. 2022 Feb 15;9:864654. doi: 10.3389/fmolb.2022.864654. eCollection 2022. PMID: 35242816 Free PMC article.

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Yang ZF, Panwar P, McFarlane CR, Tuinte WE, Campiglio M, Van Petegem F. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2120416119. doi: 10.1073/pnas.2120416119. Epub 2022 Mar 1. PMID: 35238659 Free PMC article.

Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives

Lanzetti S, Di Biase V. Molecules. 2022 Feb 15;27(4):1312. doi: 10.3390/molecules27041312. PMID: 35209100 Free PMC article. Review.

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Fernández-Quintero ML, Quoika PK, Wedl FS, Seidler CA, Kroell KB, Loeffler JR, Pomarici ND, Hoerschinger VJ, Bujotzek A, Georges G, Kettenberger H, Liedl KR. Front Mol Biosci. 2022 Jan 26;9:812750. doi: 10.3389/fmolb.2022.812750. eCollection 2022. PMID: 35155578 Free PMC article.

CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies

Fernández-Quintero ML, Kroell KB, Grunewald LJ, Fischer AM, Riccabona JR, Liedl KR. MAbs. 2022 Jan-Dec;14(1):2024118. doi: 10.1080/19420862.2021.2024118. PMID: 35090383 Free PMC article.

Explicit solvation thermodynamics in ionic solution: extending grid inhomogeneous solvation theory to solvation free energy of salt-water mixtures

Waibl F, Kraml J, Fernández-Quintero ML, Loeffler JR, Liedl KR. J Comput Aided Mol Des. 2022 Feb;36(2):101-116. doi: 10.1007/s10822-021-00429-y. Epub 2022 Jan 15. PMID: 35031880 Free PMC article.

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O’Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC. Nature. 2022 Feb;602(7896):314-320. doi: 10.1038/s41586-021-04356-8. Epub 2021 Dec 23. PMID: 34942633 Free PMC article.

Paratope states in solution improve structure prediction and docking

Fernández-Quintero ML, Vangone A, Loeffler JR, Seidler CA, Georges G, Liedl KR. Structure. 2022 Mar 3;30(3):430-440.e3. doi: 10.1016/j.str.2021.11.001. Epub 2021 Nov 26. PMID: 34838187 Free article.

Novel CACNA1A Variant p.Cys256Phe Disrupts Disulfide Bonds and Causes Spinocerebellar Ataxia

Nikonishyna YV, Ortner NJ, Kaserer T, Hoffmann J, Biskup S, Dafotakis M, Reetz K, Schulz JB, Striessnig J, Dohrn MF. Mov Disord. 2022 Feb;37(2):401-404. doi: 10.1002/mds.28835. Epub 2021 Oct 14. PMID: 34647648

Separation of the Ca_V 1.2-Ca_V 1.3 calcium channel duo prevents type 2 allergic airway inflammation

Giang N, Mars M, Moreau M, Mejia JE, Bouchaud G, Magnan A, Michelet M, Ronsin B, Murphy GG, Striessnig J, Guéry JC, Pelletier L, Savignac M. Allergy. 2022 Feb;77(2):525-539. doi: 10.1111/all.14993. Epub 2021 Jul 9. PMID: 34181765

2021

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O’Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC. Nature. 2022 Feb;602(7896):314-320. doi: 10.1038/s41586-021-04356-8. Epub 2021 Dec 23. PMID: 34942633 Free PMC article.

Paratope states in solution improve structure prediction and docking

Fernández-Quintero ML, Vangone A, Loeffler JR, Seidler CA, Georges G, Liedl KR. Structure. 2022 Mar 3;30(3):430-440.e3. doi: 10.1016/j.str.2021.11.001. Epub 2021 Nov 26. PMID: 34838187 Free article.

Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

Perrone F, Piccirillo MC, Ascierto PA, Salvarani C, Parrella R, Marata AM, Popoli P, Ferraris L, Marrocco-Trischitta MM, Ripamonti D, Binda F, Bonfanti P, Squillace N, Castelli F, Muiesan ML, Lichtner M, Calzetti C, Salerno ND, Atripaldi L, Cascella M, Costantini M, Dolci G, Facciolongo NC, Fraganza F, Massari M, Montesarchio V, Mussini C, Negri EA, Botti G, Cardone C, Gargiulo P, Gravina A, Schettino C, Arenare L, Chiodini P, Gallo C; TOCIVID-19 investigators, Italy. J Transl Med. 2021 Oct 21;19(1):442. doi: 10.1186/s12967-021-03094-9. PMID: 34674735 Free PMC article. No abstract available.

Novel CACNA1A Variant p.Cys256Phe Disrupts Disulfide Bonds and Causes Spinocerebellar Ataxia

Nikonishyna YV, Ortner NJ, Kaserer T, Hoffmann J, Biskup S, Dafotakis M, Reetz K, Schulz JB, Striessnig J, Dohrn MF. Mov Disord. 2022 Feb;37(2):401-404. doi: 10.1002/mds.28835. Epub 2021 Oct 14. PMID: 34647648

[ECB Debt Certificates – New Use for an Old Instrument?]

Hansen A, Meyer D. Wirtschaftsdienst. 2021;101(9):732-739. doi: 10.1007/s10273-021-3008-0. Epub 2021 Sep 21. PMID: 34565923 Free PMC article. German.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. Br J Pharmacol. 2021 Oct;178 Suppl 1:S157-S245. doi: 10.1111/bph.15539. PMID: 34529831 Free article.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, Ahlers-Dannen KE, Alqinyah M, Arumugam TV, Bodle C, Dagner JB, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Layeghi-Ghalehsoukhteh S, Lee JK, Luo Z, Martemyanov K, Mascarenhas LD, McNabb H, Montañez-Miranda C, Ogujiofor O, Phan H, Roman DL, Shaw V, Sjogren B, Sobey C, Spicer MM, Squires KE, Sutton L, Wendimu M, Wilkie T, Xie K, Zhang Q, Zolghadri Y. Br J Pharmacol. 2021 Oct;178 Suppl 1(Suppl 1):S1-S26. doi: 10.1111/bph.15537. PMID: 34529830 Free PMC article.

Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet

Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, Meyer D. Stem Cell Res. 2021 Oct;56:102522. doi: 10.1016/j.scr.2021.102522. Epub 2021 Sep 2. PMID: 34509159 Free article.

Ion-pair interactions between voltage-sensing domain IV and pore domain I regulate Ca_V1.1 gating

El Ghaleb Y, Fernández-Quintero ML, Monteleone S, Tuluc P, Campiglio M, Liedl KR, Flucher BE. Biophys J. 2021 Oct 19;120(20):4429-4441. doi: 10.1016/j.bpj.2021.09.004. Epub 2021 Sep 8. PMID: 34506774 Free PMC article.

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S. Mol Metab. 2021 Dec;54:101329. doi: 10.1016/j.molmet.2021.101329. Epub 2021 Aug 25. PMID: 34454092 Free PMC article.

Germline-Dependent Antibody Paratope States and Pairing Specific V_H-V_L Interface Dynamics

Fernández-Quintero ML, Kroell KB, Bacher LM, Loeffler JR, Quoika PK, Georges G, Bujotzek A, Kettenberger H, Liedl KR. Front Immunol. 2021 Aug 10;12:675655. doi: 10.3389/fimmu.2021.675655. eCollection 2021. PMID: 34447370 Free PMC article.

Role of High Voltage-Gated Ca²⁺ Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function

Tuluc P, Theiner T, Jacobo-Piqueras N, Geisler SM. Cells. 2021 Aug 6;10(8):2004. doi: 10.3390/cells10082004. PMID: 34440773 Free PMC article. Review.

Debt Relief as a Last Resort for the Lender of Last Resort?: Monetary Financing – Doing It Right

Hansen A, Meyer D. Inter Econ. 2021;56(4):223-233. doi: 10.1007/s10272-021-0984-7. Epub 2021 Aug 5. PMID: 34376869 Free PMC article.

Knockout of Ca_V1.3 L-type calcium channels in a mouse model of retinitis pigmentosa

Kilicarslan I, Zanetti L, Novelli E, Schwarzer C, Strettoi E, Koschak A. Sci Rep. 2021 Jul 26;11(1):15146. doi: 10.1038/s41598-021-94304-3. PMID: 34312410 Free PMC article.

Cav1.4 dysfunction and congenital stationary night blindness type 2

Koschak A, Fernandez-Quintero ML, Heigl T, Ruzza M, Seitter H, Zanetti L. Pflugers Arch. 2021 Sep;473(9):1437-1454. doi: 10.1007/s00424-021-02570-x. Epub 2021 Jul 1. PMID: 34212239 Free PMC article. Review.

Separation of the Ca_V 1.2-Ca_V 1.3 calcium channel duo prevents type 2 allergic airway inflammation

Giang N, Mars M, Moreau M, Mejia JE, Bouchaud G, Magnan A, Michelet M, Ronsin B, Murphy GG, Striessnig J, Guéry JC, Pelletier L, Savignac M. Allergy. 2022 Feb;77(2):525-539. doi: 10.1111/all.14993. Epub 2021 Jul 9. PMID: 34181765

Pore mutation N617D in the skeletal muscle DHPR blocks Ca²⁺ influx due to atypical high-affinity Ca²⁺ binding

Dayal A, Fernández-Quintero ML, Liedl KR, Grabner M. Elife. 2021 Jun 1;10:e63435. doi: 10.7554/eLife.63435. PMID: 34061024 Free PMC article.

Ensembles in solution as a new paradigm for antibody structure prediction and design

Fernández-Quintero ML, Georges G, Varga JM, Liedl KR. MAbs. 2021 Jan-Dec;13(1):1923122. doi: 10.1080/19420862.2021.1923122. PMID: 34030577 Free PMC article.

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation-Understanding the Potential of Shark Immunoglobulins as Therapeutics

Fernández-Quintero ML, Seidler CA, Quoika PK, Liedl KR. Front Mol Biosci. 2021 Apr 20;8:639166. doi: 10.3389/fmolb.2021.639166. eCollection 2021. PMID: 33959632 Free PMC article.

Implementation of the Freely Jointed Chain Model to Assess Kinetics and Thermodynamics of Thermosensitive Coil-Globule Transition by Markov States

Quoika PK, Fernández-Quintero ML, Podewitz M, Hofer F, Liedl KR. J Phys Chem B. 2021 May 13;125(18):4898-4909. doi: 10.1021/acs.jpcb.1c01946. Epub 2021 May 4. PMID: 33942614 Free PMC article.

Multiscale photonic imaging of the native and implanted cochlea

Keppeler D, Kampshoff CA, Thirumalai A, Duque-Afonso CJ, Schaeper JJ, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2014472118. doi: 10.1073/pnas.2014472118. PMID: 33903231 Free PMC article.

RIM-Binding Proteins Are Required for Normal Sound-Encoding at Afferent Inner Hair Cell Synapses

Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T. Front Mol Neurosci. 2021 Mar 23;14:651935. doi: 10.3389/fnmol.2021.651935. eCollection 2021. PMID: 33867935 Free PMC article.

Conformational Shifts of Stacked Heteroaromatics: Vacuum vs. Water Studied by Machine Learning

Loeffler JR, Fernández-Quintero ML, Waibl F, Quoika PK, Hofer F, Schauperl M, Liedl KR. Front Chem. 2021 Mar 26;9:641610. doi: 10.3389/fchem.2021.641610. eCollection 2021. PMID: 33842433 Free PMC article.

Structural determinants of voltage-gating properties in calcium channels

Fernández-Quintero ML, El Ghaleb Y, Tuluc P, Campiglio M, Liedl KR, Flucher BE. Elife. 2021 Mar 30;10:e64087. doi: 10.7554/eLife.64087. PMID: 33783354 Free PMC article.

Presynaptic α₂δ subunits are key organizers of glutamatergic synapses

Schöpf CL, Ablinger C, Geisler SM, Stanika RI, Campiglio M, Kaufmann WA, Nimmervoll B, Schlick B, Brockhaus J, Missler M, Shigemoto R, Obermair GJ. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e1920827118. doi: 10.1073/pnas.1920827118. PMID: 33782113 Free PMC article.

Voltage-Gated Ca²⁺-Channel α1-Subunit de novo Missense Mutations: Gain or Loss of Function – Implications for Potential Therapies

Striessnig J. Front Synaptic Neurosci. 2021 Mar 3;13:634760. doi: 10.3389/fnsyn.2021.634760. eCollection 2021. PMID: 33746731 Free PMC article. Review.

Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution

Fernández-Quintero ML, Kroell KB, Hofer F, Riccabona JR, Liedl KR. Front Immunol. 2021 Mar 2;12:630034. doi: 10.3389/fimmu.2021.630034. eCollection 2021. PMID: 33737932 Free PMC article.

Voltage-Gated Ca²⁺ Channels in Dopaminergic Substantia Nigra Neurons: Therapeutic Targets for Neuroprotection in Parkinson’s Disease?

Ortner NJ. Front Synaptic Neurosci. 2021 Feb 26;13:636103. doi: 10.3389/fnsyn.2021.636103. eCollection 2021. PMID: 33716705 Free PMC article. Review.

CACNA1I gain-of-function mutations differentially affect channel gating and cause neurodevelopmental disorders

El Ghaleb Y, Schneeberger PE, Fernández-Quintero ML, Geisler SM, Pelizzari S, Polstra AM, van Hagen JM, Denecke J, Campiglio M, Liedl KR, Stevens CA, Person RE, Rentas S, Marsh ED, Conlin LK, Tuluc P, Kutsche K, Flucher BE. Brain. 2021 Aug 17;144(7):2092-2106. doi: 10.1093/brain/awab101. PMID: 33704440 Free PMC article.

Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit α₂δ-2 Mutant (Ducky) and α₂δ Double Knockout Mice

Geisler SM, Benedetti A, Schöpf CL, Schwarzer C, Stefanova N, Schwartz A, Obermair GJ. Front Synaptic Neurosci. 2021 Feb 19;13:634412. doi: 10.3389/fnsyn.2021.634412. eCollection 2021. PMID: 33679366 Free PMC article.

Exciting leak: Na⁺ background current makes chromaffin cells burst

Tuluc P. J Physiol. 2021 Mar;599(6):1727-1728. doi: 10.1113/JP281353. Epub 2021 Feb 10. PMID: 33533486 Free PMC article. No abstract available.

Feedback control of the Gpr161-G_αs-PKA axis contributes to basal Hedgehog repression in zebrafish

Tschaikner PM, Regele D, Röck R, Salvenmoser W, Meyer D, Bouvier M, Geley S, Stefan E, Aanstad P. Development. 2021 Feb 17;148(4):dev192443. doi: 10.1242/dev.192443. PMID: 33531430

Function of cone and cone-related pathways in Ca_V1.4 IT mice

Zanetti L, Kilicarslan I, Netzer M, Babai N, Seitter H, Koschak A. Sci Rep. 2021 Feb 1;11(1):2732. doi: 10.1038/s41598-021-82210-7. PMID: 33526839 Free PMC article.

pH-Induced Local Unfolding of the Phl p 6 Pollen Allergen From cpH-MD

Hofer F, Kamenik AS, Fernández-Quintero ML, Kraml J, Liedl KR. Front Mol Biosci. 2021 Jan 12;7:603644. doi: 10.3389/fmolb.2020.603644. eCollection 2020. PMID: 33511157 Free PMC article.

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Rankovic V, Vogl C, Dörje NM, Bahader I, Duque-Afonso CJ, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T. Front Mol Neurosci. 2021 Jan 7;13:600051. doi: 10.3389/fnmol.2020.600051. eCollection 2020. PMID: 33488357 Free PMC article.

Sample chamber for synchrotron based in-situ X-ray diffraction experiments under electric fields and temperatures between 100 K and 1250 K

Nentwich M, Weigel T, Richter C, Stöcker H, Mehner E, Jachalke S, Novikov DV, Zschornak M, Meyer DC. J Synchrotron Radiat. 2021 Jan 1;28(Pt 1):158-168. doi: 10.1107/S1600577520014344. Epub 2021 Jan 1. PMID: 33399564 Free PMC article.

Stabilization of negative activation voltages of Cav1.3 L-Type Ca²⁺-channels by alternative splicing

Hofer NT, Pinggera A, Nikonishyna YV, Tuluc P, Fritz EM, Obermair GJ, Striessnig J. Channels (Austin). 2021 Dec;15(1):38-52. doi: 10.1080/19336950.2020.1859260. PMID: 33380256 Free PMC article.

Conformational Ensembles of Antibodies Determine Their Hydrophobicity

Waibl F, Fernández-Quintero ML, Kamenik AS, Kraml J, Hofer F, Kettenberger H, Georges G, Liedl KR. Biophys J. 2021 Jan 5;120(1):143-157. doi: 10.1016/j.bpj.2020.11.010. Epub 2020 Nov 18. PMID: 33220303 Free PMC article.

Conformational flexibility correlates with glucose tolerance for point mutations in β-glucosidases – a computational study

Lima LHF, Fernandez-Quintéro ML, Rocha REO, Mariano DCB, de Melo-Minardi RC, Liedl KR. J Biomol Struct Dyn. 2021 Mar;39(5):1621-1634. doi: 10.1080/07391102.2020.1734484. Epub 2020 Mar 10. PMID: 32107974

2020

pH-Induced Local Unfolding of the Phl p 6 Pollen Allergen From cpH-MD

Hofer F, Kamenik AS, Fernández-Quintero ML, Kraml J, Liedl KR. Front Mol Biosci. 2021 Jan 12;7:603644. doi: 10.3389/fmolb.2020.603644. eCollection 2020. PMID: 33511157 Free PMC article.

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Rankovic V, Vogl C, Dörje NM, Bahader I, Duque-Afonso CJ, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T. Front Mol Neurosci. 2021 Jan 7;13:600051. doi: 10.3389/fnmol.2020.600051. eCollection 2020. PMID: 33488357 Free PMC article.

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Fernández-Quintero ML, Kroell KB, Heiss MC, Loeffler JR, Quoika PK, Waibl F, Bujotzek A, Moessner E, Georges G, Liedl KR. Front Mol Biosci. 2020 Nov 24;7:609088. doi: 10.3389/fmolb.2020.609088. eCollection 2020. PMID: 33330636 Free PMC article.

Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses-A Presynaptic Perspective

Voorn RA, Vogl C. Int J Mol Sci. 2020 Nov 19;21(22):8758. doi: 10.3390/ijms21228758. PMID: 33228215 Free PMC article. Review.

Conformational Ensembles of Antibodies Determine Their Hydrophobicity

Waibl F, Fernández-Quintero ML, Kamenik AS, Kraml J, Hofer F, Kettenberger H, Georges G, Liedl KR. Biophys J. 2021 Jan 5;120(1):143-157. doi: 10.1016/j.bpj.2020.11.010. Epub 2020 Nov 18. PMID: 33220303 Free PMC article.

Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei (Blyth, 1847) and description of a new species

Roos C, Helgen KM, Miguez RP, Thant NML, Lwin N, Lin AK, Lin A, Yi KM, Soe P, Hein ZM, Myint MNN, Ahmed T, Chetry D, Urh M, Veatch EG, Duncan N, Kamminga P, Chua MAH, Yao L, Matauschek C, Meyer D, Liu ZJ, Li M, Nadler T, Fan PF, Quyet LK, Hofreiter M, Zinner D, Momberg F. Zool Res. 2020 Nov 18;41(6):656-669. doi: 10.24272/j.issn.2095-8137.2020.254. PMID: 33171548 Free PMC article.

Inducible Mosaic Cell Labeling Provides Insights Into Pancreatic Islet Morphogenesis

Freudenblum J, Meyer D, Kimmel RA. Front Cell Dev Biol. 2020 Sep 25;8:586651. doi: 10.3389/fcell.2020.586651. eCollection 2020. PMID: 33102488 Free PMC article.

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Guthmiller JJ, Lan LY, Fernández-Quintero ML, Han J, Utset HA, Bitar DJ, Hamel NJ, Stovicek O, Li L, Tepora M, Henry C, Neu KE, Dugan HL, Borowska MT, Chen YQ, Liu STH, Stamper CT, Zheng NY, Huang M, Palm AE, García-Sastre A, Nachbagauer R, Palese P, Coughlan L, Krammer F, Ward AB, Liedl KR, Wilson PC. Immunity. 2020 Dec 15;53(6):1230-1244.e5. doi: 10.1016/j.immuni.2020.10.005. Epub 2020 Oct 22. PMID: 33096040 Free PMC article.

Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial

Perrone F, Piccirillo MC, Ascierto PA, Salvarani C, Parrella R, Marata AM, Popoli P, Ferraris L, Marrocco-Trischitta MM, Ripamonti D, Binda F, Bonfanti P, Squillace N, Castelli F, Muiesan ML, Lichtner M, Calzetti C, Salerno ND, Atripaldi L, Cascella M, Costantini M, Dolci G, Facciolongo NC, Fraganza F, Massari M, Montesarchio V, Mussini C, Negri EA, Botti G, Cardone C, Gargiulo P, Gravina A, Schettino C, Arenare L, Chiodini P, Gallo C; TOCIVID-19 investigators, Italy. J Transl Med. 2020 Oct 21;18(1):405. doi: 10.1186/s12967-020-02573-9. PMID: 33087150 Free PMC article. Clinical Trial.

Antibodies exhibit multiple paratope states influencing V_H-V_L domain orientations

Fernández-Quintero ML, Pomarici ND, Math BA, Kroell KB, Waibl F, Bujotzek A, Georges G, Liedl KR. Commun Biol. 2020 Oct 20;3(1):589. doi: 10.1038/s42003-020-01319-z. PMID: 33082531 Free PMC article.

Local and Global Rigidification Upon Antibody Affinity Maturation

Fernández-Quintero ML, Loeffler JR, Bacher LM, Waibl F, Seidler CA, Liedl KR. Front Mol Biosci. 2020 Aug 7;7:182. doi: 10.3389/fmolb.2020.00182. eCollection 2020. PMID: 32850970 Free PMC article.

Shock waves promote spinal cord repair via TLR3

Gollmann-Tepeköylü C, Nägele F, Graber M, Pölzl L, Lobenwein D, Hirsch J, An A, Irschick R, Röhrs B, Kremser C, Hackl H, Huber R, Venezia S, Hercher D, Fritsch H, Bonaros N, Stefanova N, Tancevski I, Meyer D, Grimm M, Holfeld J. JCI Insight. 2020 Aug 6;5(15):e134552. doi: 10.1172/jci.insight.134552. PMID: 32759498 Free PMC article.

T-Cell Receptor CDR3 Loop Conformations in Solution Shift the Relative Vα-Vβ Domain Distributions

Fernández-Quintero ML, Pomarici ND, Loeffler JR, Seidler CA, Liedl KR. Front Immunol. 2020 Jul 8;11:1440. doi: 10.3389/fimmu.2020.01440. eCollection 2020. PMID: 32733478 Free PMC article.

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T. Sci Transl Med. 2020 Jul 22;12(553):eabb8086. doi: 10.1126/scitranslmed.abb8086. PMID: 32718992 Free PMC article.

X-ray diffraction using focused-ion-beam-prepared single crystals

Weigel T, Funke C, Zschornak M, Behm T, Stöcker H, Leisegang T, Meyer DC. J Appl Crystallogr. 2020 Apr 14;53(Pt 3):614-622. doi: 10.1107/S1600576720003143. eCollection 2020 Jun 1. PMID: 32684876 Free PMC article.

Correction to: De novo CACNA1D Ca²⁺ channelopathies: clinical phenotypes and molecular mechanism

Ortner NJ, Kaserer T, Copeland JN, Striessnig J. Pflugers Arch. 2020 Aug;472(8):1105. doi: 10.1007/s00424-020-02436-8. PMID: 32666275 Free PMC article.

Neuronal α₂δ proteins and brain disorders

Ablinger C, Geisler SM, Stanika RI, Klein CT, Obermair GJ. Pflugers Arch. 2020 Jul;472(7):845-863. doi: 10.1007/s00424-020-02420-2. Epub 2020 Jun 30. PMID: 32607809 Free PMC article. Review.

Pyroelectrically-driven chemical reactions described by a novel thermodynamic cycle

de Vivanco MU, Zschornak M, Stöcker H, Jachalke S, Mehner E, Leisegang T, Meyer DC. Phys Chem Chem Phys. 2020 Aug 24;22(32):17781-17790. doi: 10.1039/d0cp01288b. PMID: 32589174

De novo CACNA1D Ca²⁺ channelopathies: clinical phenotypes and molecular mechanism

Ortner NJ, Kaserer T, Copeland JN, Striessnig J. Pflugers Arch. 2020 Jul;472(7):755-773. doi: 10.1007/s00424-020-02418-w. Epub 2020 Jun 24. PMID: 32583268 Free PMC article. Review.

Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases

Kaehler K, Seitter H, Sandbichler AM, Tschugg B, Obermair GJ, Stefanova N, Koschak A. Invest Ophthalmol Vis Sci. 2020 Jun 3;61(6):12. doi: 10.1167/iovs.61.6.12. PMID: 32503050 Free PMC article.

Multiple Sequence Variants in STAC3 Affect Interactions with Ca_V1.1 and Excitation-Contraction Coupling

Rufenach B, Christy D, Flucher BE, Bui JM, Gsponer J, Campiglio M, Van Petegem F. Structure. 2020 Aug 4;28(8):922-932.e5. doi: 10.1016/j.str.2020.05.005. Epub 2020 Jun 2. PMID: 32492370 Free article.

Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development

Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M. J Neurosci. 2020 Jun 17;40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020. Epub 2020 May 15. PMID: 32414783 Free PMC article.

Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures

Fernández-Quintero ML, Heiss MC, Pomarici ND, Math BA, Liedl KR. MAbs. 2020 Jan-Dec;12(1):1744328. doi: 10.1080/19420862.2020.1744328. PMID: 32264741 Free PMC article.

The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development

Demetz E, Tymoszuk P, Hilbe R, Volani C, Haschka D, Heim C, Auer K, Lener D, Zeiger LB, Pfeifhofer-Obermair C, Boehm A, Obermair GJ, Ablinger C, Coassin S, Lamina C, Kager J, Petzer V, Asshoff M, Schroll A, Nairz M, Dichtl S, Seifert M, von Raffay L, Fischer C, Barros-Pinkelnig M, Brigo N, Valente de Souza L, Sopper S, Hirsch J, Graber M, Gollmann-Tepeköylü C, Holfeld J, Halper J, Macheiner S, Gostner J, Vogel GF, Pechlaner R, Moser P, Imboden M, Marques-Vidal P, Probst-Hensch NM, Meiselbach H, Strauch K, Peters A, Paulweber B, Willeit J, Kiechl S, Kronenberg F, Theurl I, Tancevski I, Weiss G. Eur Heart J. 2020 Oct 21;41(40):3949-3959. doi: 10.1093/eurheartj/ehaa140. PMID: 32227235

Skeletal muscle Ca_V1.1 channelopathies

Flucher BE. Pflugers Arch. 2020 Jul;472(7):739-754. doi: 10.1007/s00424-020-02368-3. Epub 2020 Mar 28. PMID: 32222817 Free PMC article. Review.

Emerging Approaches for Restoration of Hearing and Vision

Kleinlogel S, Vogl C, Jeschke M, Neef J, Moser T. Physiol Rev. 2020 Oct 1;100(4):1467-1525. doi: 10.1152/physrev.00035.2019. Epub 2020 Mar 19. PMID: 32191560 Free article. Review.

A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions

Coste de Bagneaux P, von Elsner L, Bierhals T, Campiglio M, Johannsen J, Obermair GJ, Hempel M, Flucher BE, Kutsche K. PLoS Genet. 2020 Mar 16;16(3):e1008625. doi: 10.1371/journal.pgen.1008625. eCollection 2020 Mar. PMID: 32176688 Free PMC article.

T-Cell Receptor Variable β Domains Rigidify During Affinity Maturation

Fernández-Quintero ML, Seidler CA, Liedl KR. Sci Rep. 2020 Mar 11;10(1):4472. doi: 10.1038/s41598-020-61433-0. PMID: 32161287 Free PMC article.

STACKED – Solvation Theory of Aromatic Complexes as Key for Estimating Drug Binding

Loeffler JR, Fernández-Quintero ML, Schauperl M, Liedl KR. J Chem Inf Model. 2020 Apr 27;60(4):2304-2313. doi: 10.1021/acs.jcim.9b01165. Epub 2020 Mar 19. PMID: 32142283 Free PMC article.

Conformational flexibility correlates with glucose tolerance for point mutations in β-glucosidases – a computational study

Lima LHF, Fernandez-Quintéro ML, Rocha REO, Mariano DCB, de Melo-Minardi RC, Liedl KR. J Biomol Struct Dyn. 2021 Mar;39(5):1621-1634. doi: 10.1080/07391102.2020.1734484. Epub 2020 Mar 10. PMID: 32107974

Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder

Hofer NT, Tuluc P, Ortner NJ, Nikonishyna YV, Fernándes-Quintero ML, Liedl KR, Flucher BE, Cox H, Striessnig J. Mol Autism. 2020 Jan 8;11(1):4. doi: 10.1186/s13229-019-0310-4. eCollection 2020. PMID: 31921405 Free PMC article.

V_H -V_L interdomain dynamics observed by computer simulations and NMR

Fernández-Quintero ML, Hoerschinger VJ, Lamp LM, Bujotzek A, Georges G, Liedl KR. Proteins. 2020 Jul;88(7):830-839. doi: 10.1002/prot.25872. Epub 2020 Jan 14. PMID: 31904133 Free PMC article.

RBP2 stabilizes slow Cav1.3 Ca²⁺ channel inactivation properties of cochlear inner hair cells

Ortner NJ, Pinggera A, Hofer NT, Siller A, Brandt N, Raffeiner A, Vilusic K, Lang I, Blum K, Obermair GJ, Stefan E, Engel J, Striessnig J. Pflugers Arch. 2020 Jan;472(1):3-25. doi: 10.1007/s00424-019-02338-4. Epub 2019 Dec 17. PMID: 31848688 Free PMC article.

Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior

Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y. Mol Psychiatry. 2020 May;25(5):1035-1049. doi: 10.1038/s41380-019-0371-y. Epub 2019 Feb 13. PMID: 30760886 Free PMC article.

2019

Conformational selection of allergen-antibody complexes-surface plasticity of paratopes and epitopes

Fernández-Quintero ML, Loeffler JR, Waibl F, Kamenik AS, Hofer F, Liedl KR. Protein Eng Des Sel. 2019 Dec 31;32(11):513-523. doi: 10.1093/protein/gzaa014. PMID: 32719844 Free PMC article.

Antibody humanization-the Influence of the antibody framework on the CDR-H3 loop ensemble in solution

Fernández-Quintero ML, Heiss MC, Liedl KR. Protein Eng Des Sel. 2019 Dec 31;32(9):411-422. doi: 10.1093/protein/gzaa004. PMID: 32129452 Free PMC article.

RBP2 stabilizes slow Cav1.3 Ca²⁺ channel inactivation properties of cochlear inner hair cells

Ortner NJ, Pinggera A, Hofer NT, Siller A, Brandt N, Raffeiner A, Vilusic K, Lang I, Blum K, Obermair GJ, Stefan E, Engel J, Striessnig J. Pflugers Arch. 2020 Jan;472(1):3-25. doi: 10.1007/s00424-019-02338-4. Epub 2019 Dec 17. PMID: 31848688 Free PMC article.

Postsynaptic Ca_V1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction

Kaplan MM, Flucher BE. Sci Rep. 2019 Dec 5;9(1):18450. doi: 10.1038/s41598-019-54900-w. PMID: 31804576 Free PMC article.

Transitions of CDR-L3 Loop Canonical Cluster Conformations on the Micro-to-Millisecond Timescale

Fernández-Quintero ML, Math BA, Loeffler JR, Liedl KR. Front Immunol. 2019 Nov 19;10:2652. doi: 10.3389/fimmu.2019.02652. eCollection 2019. PMID: 31803187 Free PMC article.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S1-S20. doi: 10.1111/bph.14747. PMID: 31710719 Free PMC article. Review.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S142-S228. doi: 10.1111/bph.14749. PMID: 31710715 Free PMC article. Review.

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B. Nat Commun. 2019 Nov 8;10(1):5094. doi: 10.1038/s41467-019-12834-x. PMID: 31704946 Free PMC article.

FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation

Fischer P, Chen H, Pacho F, Rieder D, Kimmel RA, Meyer D. BMC Biol. 2019 Jul 30;17(1):61. doi: 10.1186/s12915-019-0683-z. PMID: 31362746 Free PMC article.

Deletion of the Ca²⁺ Channel Subunit α₂δ3 Differentially Affects Ca_v2.1 and Ca_v2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing

Stephani F, Scheuer V, Eckrich T, Blum K, Wang W, Obermair GJ, Engel J. Front Cell Neurosci. 2019 Jun 26;13:278. doi: 10.3389/fncel.2019.00278. eCollection 2019. PMID: 31293392 Free PMC article.

Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Emfinger CH, Lőrincz R, Wang Y, York NW, Singareddy SS, Ikle JM, Tryon RC, McClenaghan C, Shyr ZA, Huang Y, Reissaus CA, Meyer D, Piston DW, Hyrc K, Remedi MS, Nichols CG. Physiol Rep. 2019 Jun;7(11):e14101. doi: 10.14814/phy2.14101. PMID: 31161721 Free PMC article.

CDR-H3 loop ensemble in solution – conformational selection upon antibody binding

Fernández-Quintero ML, Kraml J, Georges G, Liedl KR. MAbs. 2019 Aug/Sep;11(6):1077-1088. doi: 10.1080/19420862.2019.1618676. Epub 2019 Jun 9. PMID: 31148507 Free PMC article.

The Aluminum-Ion Battery: A Sustainable and Seminal Concept?

Leisegang T, Meutzner F, Zschornak M, Münchgesang W, Schmid R, Nestler T, Eremin RA, Kabanov AA, Blatov VA, Meyer DC. Front Chem. 2019 May 1;7:268. doi: 10.3389/fchem.2019.00268. eCollection 2019. PMID: 31119122 Free PMC article. Review.

Sulfur- and Selenium-Containing Compounds Potentially Exhibiting Al Ion Conductivity

Meutzner F, Zschornak M, Kabanov AA, Nestler T, Leisegang T, Blatov VA, Meyer DC. Chemistry. 2019 Jun 26;25(36):8623-8629. doi: 10.1002/chem.201901438. Epub 2019 May 30. PMID: 31012511

Quality of life in pre- and postmenopausal patients with early breast cancer: a comprehensive analysis from the prospective MaLife project

Marschner N, Trarbach T, Rauh J, Meyer D, Müller-Hagen S, Harde J, Dille S, Kruggel L, Jänicke M; TMK-Group (Tumour Registry Breast Cancer). Breast Cancer Res Treat. 2019 Jun;175(3):701-712. doi: 10.1007/s10549-019-05197-w. Epub 2019 Mar 13. PMID: 30868393 Free PMC article.

Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea

Michanski S, Smaluch K, Steyer AM, Chakrabarti R, Setz C, Oestreicher D, Fischer C, Möbius W, Moser T, Vogl C, Wichmann C. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6415-6424. doi: 10.1073/pnas.1812029116. Epub 2019 Mar 13. PMID: 30867284 Free PMC article.

Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior

Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wei J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y. Mol Psychiatry. 2020 May;25(5):1035-1049. doi: 10.1038/s41380-019-0371-y. Epub 2019 Feb 13. PMID: 30760886 Free PMC article.

Effect of Charge Transfer upon Li- and Na-Ion Insertion in Fine-Grained Graphitic Material as Probed by NMR

Vyalikh A, Koroteev VO, Münchgesang W, Köhler T, Röder C, Brendler E, Okotrub AV, Bulusheva LG, Meyer DC. ACS Appl Mater Interfaces. 2019 Mar 6;11(9):9291-9300. doi: 10.1021/acsami.8b20115. Epub 2019 Feb 21. PMID: 30741532

Endophilin-A regulates presynaptic Ca²⁺ influx and synaptic vesicle recycling in auditory hair cells

Kroll J, Jaime Tobón LM, Vogl C, Neef J, Kondratiuk I, König M, Strenzke N, Wichmann C, Milosevic I, Moser T. EMBO J. 2019 Mar 1;38(5):e100116. doi: 10.15252/embj.2018100116. Epub 2019 Feb 7. PMID: 30733243 Free PMC article.

Presynaptic α₂δ-2 Calcium Channel Subunits Regulate Postsynaptic GABA_A Receptor Abundance and Axonal Wiring

Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ. J Neurosci. 2019 Apr 3;39(14):2581-2605. doi: 10.1523/JNEUROSCI.2234-18.2019. Epub 2019 Jan 25. PMID: 30683685 Free PMC article.

Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties

Fernández-Quintero ML, Loeffler JR, Kraml J, Kahler U, Kamenik AS, Liedl KR. Front Immunol. 2019 Jan 7;9:3065. doi: 10.3389/fimmu.2018.03065. eCollection 2018. PMID: 30666252 Free PMC article.

Correcting the R165K substitution in the first voltage-sensor of Ca_V1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation

El Ghaleb Y, Campiglio M, Flucher BE. Channels (Austin). 2019 Dec;13(1):62-71. doi: 10.1080/19336950.2019.1568825. PMID: 30638110 Free PMC article.

Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers

Calorio C, Gavello D, Guarina L, Salio C, Sassoè-Pognetto M, Riganti C, Bianchi FT, Hofer NT, Tuluc P, Obermair GJ, Defilippi P, Balzac F, Turco E, Bett GC, Rasmusson RL, Carbone E. J Physiol. 2019 Mar;597(6):1705-1733. doi: 10.1113/JP277487. Epub 2019 Jan 28. PMID: 30629744 Free PMC article.

The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson’s Disease

Liss B, Striessnig J. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:263-289. doi: 10.1146/annurev-pharmtox-010818-021214. PMID: 30625283 Review.

STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function

Flucher BE, Campiglio M. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1101-1110. doi: 10.1016/j.bbamcr.2018.12.004. Epub 2018 Dec 10. PMID: 30543836 Free article. Review.

2018

Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties

Fernández-Quintero ML, Loeffler JR, Kraml J, Kahler U, Kamenik AS, Liedl KR. Front Immunol. 2019 Jan 7;9:3065. doi: 10.3389/fimmu.2018.03065. eCollection 2018. PMID: 30666252 Free PMC article.

STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function

Flucher BE, Campiglio M. Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1101-1110. doi: 10.1016/j.bbamcr.2018.12.004. Epub 2018 Dec 10. PMID: 30543836 Free article. Review.

Getting a handle on Ca_V2.2 (N-type) voltage-gated Ca²⁺ channels

Striessnig J. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12848-12850. doi: 10.1073/pnas.1818608115. Epub 2018 Dec 11. PMID: 30538200 Free PMC article. No abstract available.

In vivo monitoring of intracellular Ca²⁺ dynamics in the pancreatic β-cells of zebrafish embryos

Lorincz R, Emfinger CH, Walcher A, Giolai M, Krautgasser C, Remedi MS, Nichols CG, Meyer D. Islets. 2018;10(6):221-238. doi: 10.1080/19382014.2018.1540234. Epub 2018 Dec 6. PMID: 30521410 Free PMC article.

Gating defects of disease-causing de novo mutations in Ca_v1.3 Ca²⁺ channels

Pinggera A, Negro G, Tuluc P, Brown MJ, Lieb A, Striessnig J. Channels (Austin). 2018;12(1):388-402. doi: 10.1080/19336950.2018.1546518. PMID: 30465465 Free PMC article.

[Hyperlipidemia: What role do PCSK9 inhibitors play?]

Meyer D, Merkel M. Dtsch Med Wochenschr. 2018 Oct;143(20):1430-1434. doi: 10.1055/a-0635-7114. Epub 2018 Oct 4. PMID: 30286489 German.

Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses

Pangrsic T, Vogl C. FEBS Lett. 2018 Nov;592(21):3633-3650. doi: 10.1002/1873-3468.13258. Epub 2018 Oct 9. PMID: 30251250 Free article. Review.

Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance

Hagiwara A, Kitahara Y, Grabner CP, Vogl C, Abe M, Kitta R, Ohta K, Nakamura K, Sakimura K, Moser T, Nishi A, Ohtsuka T. J Cell Biol. 2018 Nov 5;217(11):3993-4006. doi: 10.1083/jcb.201704076. Epub 2018 Sep 6. PMID: 30190286 Free PMC article.

STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor

Campiglio M, Kaplan MM, Flucher BE. J Cell Physiol. 2018 Dec;233(12):9045-9051. doi: 10.1002/jcp.26767. Epub 2018 Aug 2. PMID: 30071129 Free PMC article.

Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear

Pangrsic T, Singer JH, Koschak A. Physiol Rev. 2018 Oct 1;98(4):2063-2096. doi: 10.1152/physrev.00030.2017. PMID: 30067155 Free PMC article. Review.

Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca_V1.2 and Ca_V1.3 calcium channels

Costé de Bagneaux P, Campiglio M, Benedetti B, Tuluc P, Flucher BE. Channels (Austin). 2018;12(1):249-261. doi: 10.1080/19336950.2018.1482183. PMID: 30001160 Free PMC article.

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

Wrobel C, Dieter A, Huet A, Keppeler D, Duque-Afonso CJ, Vogl C, Hoch G, Jeschke M, Moser T. Sci Transl Med. 2018 Jul 11;10(449):eaao0540. doi: 10.1126/scitranslmed.aao0540. PMID: 29997248

Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation

Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE. Cell Rep. 2018 Jun 26;23(13):3891-3904. doi: 10.1016/j.celrep.2018.05.085. PMID: 29949772 Free article.

Protein kinase N1 critically regulates cerebellar development and long-term function

zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G. J Clin Invest. 2018 May 1;128(5):2076-2088. doi: 10.1172/JCI96165. Epub 2018 Apr 16. PMID: 29494346 Free PMC article.

Rituximab in combination with chemotherapy for the treatment of chronic lymphocytic leukaemia in clinical practice

Reiser M, Dörfel S, Hensel M, Hoesl M, Jordan WO, Koenigsmann M, Meyer D, Reichert D, Schwarzer A, Marquardt M, Kellershohn K, Jentsch-Ullrich K. Eur J Haematol. 2018 May;100(5):455-464. doi: 10.1111/ejh.13040. Epub 2018 Mar 22. PMID: 29393986

In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis

Freudenblum J, Iglesias JA, Hermann M, Walsen T, Wilfinger A, Meyer D, Kimmel RA. Development. 2018 Feb 8;145(3):dev158477. doi: 10.1242/dev.158477. PMID: 29386244 Free PMC article.

STAC proteins associate to the IQ domain of Ca_V1.2 and inhibit calcium-dependent inactivation

Campiglio M, Costé de Bagneaux P, Ortner NJ, Tuluc P, Van Petegem F, Flucher BE. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1376-1381. doi: 10.1073/pnas.1715997115. Epub 2018 Jan 23. PMID: 29363593 Free PMC article.

Picometer polar atomic displacements in strontium titanate determined by resonant X-ray diffraction

Richter C, Zschornak M, Novikov D, Mehner E, Nentwich M, Hanzig J, Gorfman S, Meyer DC. Nat Commun. 2018 Jan 12;9(1):178. doi: 10.1038/s41467-017-02599-6. PMID: 29330508 Free PMC article.

Adjuvant chemotherapeutic treatment of 1650 patients with early breast cancer in routine care in Germany: data from the prospective TMK cohort study

Dörfel S, Steffens CC, Meyer D, Tesch H, Kruggel L, Frank M, Jänicke M, Marschner N; TMK-Group (Tumour Registry Breast Cancer). Breast Cancer. 2018 May;25(3):275-283. doi: 10.1007/s12282-017-0823-7. Epub 2017 Dec 4. PMID: 29204847 Free PMC article.

Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of Ca_V1.2 calcium channels in hippocampal neurons

Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V. J Biol Chem. 2018 Jan 19;293(3):1040-1053. doi: 10.1074/jbc.M117.799585. Epub 2017 Nov 27. PMID: 29180451 Free PMC article.

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy

Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D’Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro TF, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO. EMBO J. 2018 Jan 4;37(1):139-159. doi: 10.15252/embj.201695709. Epub 2017 Nov 16. PMID: 29146773 Free PMC article.

Relevance of tissue specific subunit expression in channelopathies

Seitter H, Koschak A. Neuropharmacology. 2018 Apr;132:58-70. doi: 10.1016/j.neuropharm.2017.06.029. Epub 2017 Jun 29. PMID: 28669898 Free PMC article. Review.

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