//     ENIKÖ TÖRÖK

Campiglio Research Group
Institute of Physiology,
Medical University of Innsbruck

//     INFORMATION

Nationality: Hungarian
Education: MSc in Pharmaceutical Biotechnology University of Debrecen
E-Mail: enikoe.toeroek@i-med.ac.at

Supervisor: Marta Campiglio PhD (Medical University)

//     PROJECT

Recently the hitherto unnoticed scaffold protein STAC3 has been shown to be essential for excitation–contraction (EC) coupling, as it is crucial for the expression, stability and function of the voltage–sensor of EC coupling CaV1.1 and for voltage–induced calcium release from the sarcoplasmic reticulum (SR). Furthermore, STAC3 was shown to establish two distinct interactions with CaV1.1. However, whether a single interaction or both contribute to each function of STAC3 remains elusive. In my project we will take advantage of a newly generated genetic muscle cell model (STAC3 KO) and a range of available and new molecular constructs to dissect the functions of the multiple STAC3/CaV1.1 interaction.

Methods: Site–directed mutagenesis, Immunocytochemistry, Western blot analysis, protein extraction, CRISPR/Cas9 gene editing, cell culture and transfection, fluorescent microscopy, high–resolution microscopy.

//     INTERNAL COLLABORATIONS